| Multiprogramming OS is designed to maximize CPU utilization on a single processor or CPU core. | Multiprocessing OS is designed to take advantage of multiple processors or CPU cores present in a computer system. |
| Multiple programs are loaded into memory simultaneously, and the CPU switches between these programs to execute their instructions. | Multiple programs or tasks can execute truly simultaneously on different CPUs or cores. |
| Overlapping of I/O and CPU operations enhances CPU utilization. | Each CPU/core works independently. |
| At any given moment, only one program is actively executing on the CPU. | True parallelism is achieved by executing multiple programs concurrently on separate CPUs. |