How have technological interventions facilitated the creation of new knowledge in understanding the world beyond the naked eye?

Technological interventions such as microscopes have helped scientists study structures that cannot be seen with the unaided eye. Robert Hooke first observed cells in a thin slice of cork using a self-designed microscope. Light microscopes later helped students and scientists observe cells and their basic parts with better magnification and resolution. Powerful electron microscopes further revealed the fine details of cell structure, including many cell organelles, at the nanometre scale. Thus, improvements in magnification, resolution and contrast have created new knowledge about cells and the microscopic world.